"This study suggests that detecting decreased venous vasculature visibility (smaller veins) can distinguish MSers from healthy controls. It is interesting that MSers have a reduced venous volume; if there was an obstruction to flow, as proposed with the CSSVI hypothesis, you would expect an increased volume due to distension of the veins."
"Blood volume and flow is proportional to the tissue requirements of oxygen and glucose; i.e. reduced brain volume less blood flow hence reduced venous volume. As MS is associated with brain atrophy, from nerve cell and axonal loss, you would expect MSers to have reduced blood flow and venous volumes. Therefore the correct comparator for this study would be another disease control group, of a similar age, that has a similar degree of brain atrophy. Normal controls are a poor comparator group. Finally, this is a small study and hence will need to be reproduced."